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May 242018

“The 3D Structure of Telomerase: Uncovering Its Role in Human Disease

ARTICLE   Apr 30, 2018 | by Laura Elizabeth Mason, Science Writer, Technology Networks” (https://www.technologynetworks.com/drug-discovery/articles/the-3d-structure-of-telomerase-uncovering-its-role-in-human-disease-300278; obtained on 5-24-2018) began the following way:

“Researchers have published the first detailed picture and description of the 3-dimensional molecular structure of telomerase – a discovery that could enable better targeted drug screening and could result in more successful telomerase-related clinical therapeutics.

What does telomerase do?

The telomerase enzyme is a eukaryotic ribonucleoprotein (RNP) that repeatedly synthesizes and adds short species-dependent repeats to the 3’ end of telomeres, combating the loss of telomeres during genome replication.1,2

Telomerase was initially discovered in the unicellular eukaryote Tetrahymena thermophila in 1985 by Carol Greider and Elizabeth Blackburn3 – 12 years later it was discovered in humans. Telomerase has been found to be absent in the majority of ‘normal’ somatic cells in humans. However, its presence in over 90% of cancerous cells has ignited efforts to design drugs to target it.”

The Author is a current shareholder of Geron which supports the clinical stage development of imetelstat, a telomerase inhibitor for the treatment of hematologic myeloid malignancies.


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