“The 3D Structure of Telomerase: Uncovering Its Role in Human Disease
ARTICLE Apr 30, 2018 | by Laura Elizabeth Mason, Science Writer, Technology Networks” (https://www.technologynetworks.com/drug-discovery/articles/the-3d-structure-of-telomerase-uncovering-its-role-in-human-disease-300278; obtained on 5-24-2018) began the following way:
“Researchers have published the first detailed picture and description of the 3-dimensional molecular structure of telomerase – a discovery that could enable better targeted drug screening and could result in more successful telomerase-related clinical therapeutics.
Telomerase was initially discovered in the unicellular eukaryote Tetrahymena thermophila in 1985 by Carol Greider and Elizabeth Blackburn3 – 12 years later it was discovered in humans. Telomerase has been found to be absent in the majority of ‘normal’ somatic cells in humans. However, its presence in over 90% of cancerous cells has ignited efforts to design drugs to target it.”
The Author is a current shareholder of Geron which supports the clinical stage development of imetelstat, a telomerase inhibitor for the treatment of hematologic myeloid malignancies.
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